Chosen Solution
After replacing the front glass on my iPad the Home button isn’t working. Everything else seems to be fine.
If you are using the same home button and it was working before, you should remove the digitizer again, remove the adhesive that holds the digitizer and put back on temporarily to test. the contacts of the home button may not be making contact and raised slightly due to the adhesive being a bit too thick. if that does not fix it, check the flex connection, or you may have a faulty button.